Pistacia vera
Pistachio syrup
Development framework, evidence gaps and required checks arising from Sikalias Pharmacy experience.
Stasinos Chr. Sikalias · The science of compounding
Quality of allergen preparations
Compounding documentation meets specialist clinical care.
Allergen immunotherapy requires specialist collaboration, strict material identity and justified quality. These pages do not provide initiation, escalation or restart schedules.
The laboratory challenge
Nut mass, total protein and allergenic activity are different quantities. A nominal raw-material input does not establish the concentration reaching the final container or syringe. The assessment must also cover changes caused by processing.
| Critical question | Required evidence |
|---|---|
| What exactly is received? | Species, lot, processing, specifications and suitable analytical basis. |
| What changes during heating and filtration? | Actual parameters, recovery and final-matrix analysis. |
| Is every withdrawal consistent? | Uniformity, redispersibility and dosing-device compatibility. |
| How long does it remain suitable? | Combined physical, chemical and microbiological evidence, including in-use and packaging conditions. |
Two separate technical dossiers
Arachis hypogaea
Peanut suspension
Development framework, evidence gaps and required checks arising from Sikalias Pharmacy experience.
Dedicated SOPs
- OIT-001 · Allergist interface and order verification
- OIT-002 · Allergen identity and protein basis
- OIT-003 · Allergen segregation and staff protection
- OIT-004 · Controlled processing and protein recovery
- OIT-005 · Uniformity, redispersibility and dosing device
- OIT-006 · Microbiology, packaging and stability
- OIT-007 · Allergen label and safe handover
- OIT-008 · Incident, recall and reassessment
What the clinical sources support
EAACI guidance places food-allergy immunotherapy within specialist teams experienced in managing reactions. The peanut recommendation is not a blanket recommendation for all nuts. PALFORZIA is a specific standardised product; its evidence does not establish equivalence of an individually compounded preparation.