Methodology & Evidence Hierarchy

Evidence hierarchy

1. Current official pharmacopoeia or national formulary source.
2. Recognised peer-reviewed stability and compatibility evidence.
3. Product-specific analytical, microbiological and packaging data.
4. Documented professional risk assessment where evidence remains incomplete.

Before adopting a formula

• Confirm the patient, prescription and clinical intent.
• Verify calculations, potency, solubility, pH, excipient compatibility and dosage-form suitability.
• Qualify ingredients, packaging and equipment.
• Define process controls, in-process checks and release requirements.
• Establish a justified BUD and storage instruction.
• Complete the master formula and individual compounding record.