Stasinos Chr. Sikalias · The science of compounding

Capsule diluent 1 EX013

CGR-ES-049 · FN/2003/EX/013 EXCIPIENTE N.º 1 PARA CÁPSULAS

For local reviewCGR-ES-049Spain · AEMPS

WORKSHEET FOR LOCAL APPROVAL — source authority does not replace batch approval.

Dosage formPowder excipient
Reference batch100 g
Monograph version4.0
Source packagev4

Source formula

IngredientSource quantity
Microcrystalline cellulose98.05 g
Colloidal anhydrous silica1.95 g

Quantities refer to the source batch. This website does not automatically scale formulas, assign doses or calculate BUD.

Description

Documented in source

White powder.

References: [1]

Use and action

Documented in source

Base or auxiliary excipient for further compounding. Its BUD is not adopted unchanged after adding an active.

References: [1]

Specifications

Documented in source

White powder.

References: [1]

Light

Partial evidence

For the finished product the source specifies:
Opaque jar; protect from excessive heat, direct sunlight and moisture.

References: [1]

Air

Not established

No specific information is established by the consulted sources. Complete this before local approval where critical to this preparation.

References: [1]

Water and solubility

Not established

No specific information is established by the consulted sources. Complete this before local approval where critical to this preparation.

References: [1]

Humidity

Partial evidence

For the finished product the source specifies:
Opaque jar; protect from excessive heat, direct sunlight and moisture.

References: [1]

Temperature

Not established

No specific information is established by the consulted sources. Complete this before local approval where critical to this preparation.

References: [1]

pH and related incompatibilities

Not established

No specific information is established by the consulted sources. Complete this before local approval where critical to this preparation.

References: [1]

Other incompatibilities

Not established

No specific information is established by the consulted sources. Complete this before local approval where critical to this preparation.

References: [1]

Ingredient-specific information

Not established

No specific information is established by the consulted sources. Complete this before local approval where critical to this preparation.

References: [1]

Personal protective equipment

Partial evidence

Complete formula-specific PPE is not specified. Select gloves, eye protection and exposure controls using the exact materials’ SDS and the local risk assessment.
Supplementary AEMPS framework: clean long-sleeved laboratory clothing, hair covering and dedicated footwear/overshoes. Powder handling requires suitable eye/respiratory protection; change gloves with activity or damage. Select the exact type/material using SDS and risk assessment.

References: [1] · [2]

Risks and precautions

Partial evidence

A complete formula-specific hazard classification is not established. Assess potency, dust/aerosol, allergens, solvents, microbial risk and cross-contamination using the actual materials and process. Absence of a flag does not establish absence of hazard.

References: [1]

Compounding conditions

Partial evidence

Follow the addition sequence, temperatures and times stated under Preparation Procedure. The specific monograph is not a complete qualification of the local facility/equipment.

References: [1]

BUD rationale

Documented in source

6 months under the source conditions.
The source period applies to its exact composition, method and packaging. It is not this batch’s expiry date and cannot be transferred to another vehicle/strength. Calculate the actual date in the blank batch record.

References: [1]

Bases and dependencies

Partial evidence

No separate base is identified in the dependency register. Check any commercial vehicles/compound excipients listed in the formula.

References: [1]

Equipment

Editorial checklist

Indicative checklist derived from the method: Balance of suitable resolution, Containers and mixing tools compatible with the materials, Mortar and pestle. Selection/qualification is defined locally.

References: [1]

Preparation procedure

Documented in source

Mix one third of the MCC with colloidal silica. Add and mix the second and final thirds successively. Use 15–30 min depending on quantity, in a tumbling mixer or, for small quantities only, a mortar.

References: [1] · [3]

Observations

Not established

No specific information is established by the consulted sources. Complete this before local approval where critical to this preparation.

References: [1]

Packaging

Documented in source

Opaque jar; protect from excessive heat, direct sunlight and moisture.

References: [1]

Quality control

Partial evidence

White powder.

References: [1]

Storage

Documented in source

Opaque jar; protect from excessive heat, direct sunlight and moisture.

References: [1]

Dispensing and directions

Partial evidence

No additional special directions are established beyond the source route, storage and notes. Complete patient details, dose and directions from the prescription.

References: [1]

Labelling

editorial_specimen

Capsule diluent 1 EX013
Strength/variant: __________ Quantity: __________
Batch: __________ Prepared: __________ Use by: __________
Για εργαστηριακή ενσωμάτωση / For incorporation during compounding
Dose/directions: __________
Storage: Opaque jar; protect from excessive heat, direct sunlight and moisture.

References: [1]

Sources and traceability

  1. FN/2003/EX/013 EXCIPIENTE N.º 1 PARA CÁPSULAS

    FN/2003 • ηλεκτρονικό κείμενο με NIPO 2020/2022 / electronic text with NIPO 2020/2022 · PDF pp. 2 · A1

    Review date reported in supplied metadata: 2026-09-10

  2. PN/L/PG/002/00 INDUMENTARIA

    Διαθέσιμο κείμενο / Retrieved text · PDF pp. 1–5 · A1

    Review date reported in supplied metadata: 2026-09-10

  3. PN/L/OF/002/00 MEZCLADO DE POLVOS

    Διαθέσιμο κείμενο / Retrieved text · PDF pp. 1–6 · A1

    Review date reported in supplied metadata: 2026-09-10

Provenance and reuse

This record comes from the supplied v4 collection. Primary-source rights and licences remain separate. No new comprehensive licence review has been performed for the earlier 239 records.

SHA-256 of the supplied PDF: c2e04057e28bcdb5436d8ca91d289e35b8540920e0eca43d37a56493a9696e2a